ABSTRACT
This experiment pursued the time course of contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) and histologic changes of the cutaneous reaction in mice. The contact hypersensitivity reached a maximum 4 days after sensitization (96.9 +/- 6.7% vs. 22.7 +/- 1.3% in control) and persisted for 3 weeks. The cutaneous hypersensitivity reaction showed peak reactivity at 24 hr after challenge (96.2 +/- 4.7% vs. 11.5 +/- 1.7% in control), and persisted up to 96 hr (13.2 +/- 2.1%). Prime histologic changes observed in this experiment were the exocytosis of lymphoid cells and epidermal thickening which appeared at 20 hr after challenge. Edema, vasodilatation and increased mast cells were observed within the dermis at 4-8 hr. However, edema and vasodilatation disappeared gradually, but numbers of mast cell increased up to 96 hr. The dermal infiltrates were maximum at the 28-72 hr after challenge.
Subject(s)
Animals , Female , Mice , Dermatitis, Contact/immunology , Dinitrofluorobenzene/pharmacology , Ear , Mice, Inbred BALB C , Nitrobenzenes/pharmacology , Time FactorsABSTRACT
S.I. of TCSA PCH (group B) and musk ambrette PCH (group D) were respectively g3 49% and 75.00 S.I. of group A and B, which were only challenged with TCSA and musk ambrette respectively without prior sensitization, were 33, 33% and 27. 78%. These data indicated the TCSA PCH (group B) was experimentally produced in guinea pigs when it compared to musk ambrette PCH (group D) and controls (group A and C) (Table 1). However, S.I. of TCSA PCH was somewhat lower than index of musk ambrette PCH.
Subject(s)
Animals , Guinea Pigs , Guinea , HypersensitivityABSTRACT
Urethral duplication is rare congenital anomaly. It may be complete or partial, We report a case of PPNG urethritis which limited to the accessory urethra and treated with kanamycin (2. 0gm, im), ampicillin(3. 5gm, po) and probenecid(l pgm, po).
Subject(s)
Kanamycin , Urethra , UrethritisABSTRACT
A 19-year-old man noticed a very slowly spreading erythematous macular lesion on his cheek when he was 5 years old. This asymptomatic and well circumscribed patch was covered with fine scales. He sought first medical attention at the age of 12 years and diagnosis was cutaneous tuberculosis was made by skin biopsy. Seven years after the second biopsy was made and it revealed a few spores within giant cells in the upper dermis. By mycologic study, it was identified as Paecilomyces lilacinus. The patient was put on the treatment of topical and oral antifungal agents. The skin lesion showed signs of improvement after 12 weeks of treatment.
Subject(s)
Child, Preschool , Humans , Young Adult , Antifungal Agents , Biopsy , Cheek , Dermis , Diagnosis , Giant Cells , Paecilomyces , Skin , Spores , Tuberculosis, Cutaneous , Weights and MeasuresABSTRACT
Urticaria pigmentosa developed in twins at the age of 6 weeks. They have numerous round to oval shaped, discrete or confluent reddish brown colored macules over whole body surface and neither twin had vomiting, diarrhea, flushing or irritability. Their relatives are unaffected. Biopsy specimen of. back lesion showed. pooling of mast cells in the upper dermis, and electron microscopic examinattion revealed normal mast cells.
Subject(s)
Humans , Biopsy , Dermis , Diarrhea , Flushing , Mast Cells , Twins , Urticaria Pigmentosa , Urticaria , VomitingABSTRACT
The current experiment pursued the time course of UVB-induced immune suppression of DNCB contact hypersensitivity(CHS) in guinea pigs. Both group B and C, received suberythemal doses of UVB on days -3, -2, -1, 0 and -6, -5, -4, 3 respectively, showed marked suppressions of CHS (56.36p;and56.25p,). However, the recovery of CHS from the UVB-induced suppression started by group D(UVB on days -9, -8, -7, -6: 67. 36%) and further extended to subsequent group E(UVB on days -12, -11, -10, -9: 78.82%), Group F(UVB on days -15, -14, -13, -12: 79.86%) and the final group G(UVB on days -18, -17, -16, -15: 81. 94%) in which the recovery of CHS slightly exceeded the control (group A:79. 86%).
Subject(s)
Animals , Dermatitis, Contact , Dinitrochlorobenzene , Guinea Pigs , GuineaABSTRACT
Microsportcm gypseum is a geophilic fungi abundant in soil throughout the world. The infections may occur either from animal to man(zoophilic) or from soil to man (geophilic). Patierit of 13-year-old Korean male sought medical attention with skin lesion on scalp which showed scaly patch with broken hairs and a round pilar cyst like nodule. Identification of Microsporum gypseum was made by culture on Sabouraud agar media and microscopic exarnination.